Search on: NOD SIGNALING ADAPTOR PROTEINS 
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Descriptor English:   Nod Signaling Adaptor Proteins 
Descriptor Spanish:   Proteínas Adaptadoras de Señalización NOD 
Descriptor Portuguese:   Proteínas Adaptadoras de Sinalização NOD 
Synonyms English:   Nuclear-Binding Oligomerization Domain Proteins  
Tree Number:   D12.644.360.024.307
D12.776.157.057.068
D12.776.476.024.391
Definition English:   Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. Many members of this class contain a C-terminal leucine rich domain which binds to PEPTIDOGLYCAN on the surface of BACTERIA and plays a role in pathogen resistance. 
History Note English:   2007 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   52314 
Unique Identifier:   D053472 

Occurrence in VHL:
 

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